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Contraindicated (one)pentobarbital will lower the level or influence of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is answerable for the formation and elimination of cariprazine's Energetic metabolites.pentobarbital increases effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism.